OrganRegen-Hydrocortisone（C502370）
OrganRegen-Hydrocortisone（C502370）
货号：C502370
规格：500mg
品牌：OrganRegen
Hydrocortisone
货号：C502370
规格：500mg
品牌：OrganRegen
产品介绍
DESCRIPTION
Hydrocortisone is a steroid hormone or glucocorticoid secreted by the adrenal cortex[1]. | |||
Alias | Cortisol；氢化可的松；17-羟基皮质 (甾) 酮；皮质甾醇；氢化皮质素 | ||
M. W t | 362.46 | ||
Formula | C21H30O5 | ||
CAS No | 50-23-7 | ||
Storage | Powder | -20 °C | 3 years |
In solvent | -80 °C | 6 months | |
-20 °C | 1 month | ||
Solubility | DMSO H2O : < 0.1 mg/mL | ≥ 31 mg/mL(85.53 mM)
| |
Ethanol | 23 mg/mL(63.46 mM) | ||
H2O | < 0.1 mg/mL(insoluble) | ||
BIOLOGICAL ALTIVITY
Hydrocortisone (50 nM) shows a dose-dependent down-regulation of GR transcript in hCMEC/D3 cells. Hydrocortisone supplementation of the serum-reduced cell differentiation medium leads to a significant increase in TER across the hCMEC/D3 monolayer[1]. Hydrocortisone-treated Dendritic cells (DCs) show a decreased expression of MHC II molecules, the costimulatory molecule CD86, and the DC-specific marker CD83, as well as a strongly reduced IL-12 secretion. Hydrocortisone-treated DCs inhibit production of IFN-γ but induce an increased release of IL-4 and no change in IL-5[2]. Hydrocortisone reduces postischemic oxidative stress, perfusion pressure, and transudate formation. Hydrocortisone inhibits postischemic shedding of syndecan-1, heparan sulfate, and hyaluronan as is release of histamine from resident mast cells[3].
In Vivo
Boston Children´s Hospital | Adrenal Hyperplasia, Congenital | Phase 2 | |
NCT03910088 | Cairo University | Post-Dural Puncture Headache | Phase 4 |
NCT00657306 | University of Turin, Italy | Cirrhosis With Ascites | Phase 2 |
REFERENCES
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